Aust N Z J Psychiatry ; Godemann, F, Hellweg, R. Am J Psychiatry ; In this report, we present a case of a young Caucasian male patient being titrated on clozapine, who developed myocarditis after an atypical presentation that could have been mistaken for other, more common causes of his symptoms.
This was his only temperature spike. ECT for treatment-resistant schizophrenia: Combined ECT and clozapine in treatment-resistant mania.
In addition to its superior efficacy for patients resistant to conventional antipsychotic drugs, clozapine also is the only medication currently approved by the Food and Drug Administration for the treatment of suicidal behavior.
Initially, it was felt that the most likely diagnosis was common side effects of clozapine. Signs and symptoms include chest pain, dyspnoea, signs of heart failure, tachycardia, pyrexia, and other less well-defined symptoms such as viral prodrome-like symptoms.
Electroconvulsive therapy and clozapine in adolescents with schizophrenia spectrum disorders: Safferman, AZ, Munne, R. Given the number of patients initiated on clozapine and the fact that patients on clozapine may well reside in the community, nurse led monitoring may be a way to bring in some of the proposed monitoring protocols on the large scale required [ 51415 ].
Indian J Psychol Med ; Shanghai Arch Psychiatry ; Follow-up on clozapine and ECT. It was felt important to rule out the possibility of neuroleptic malignancy syndrome, which was done after the normal creatine kinase value.
Int Clin Psychopharmacol ; Augmentation strategies in patients with schizophrenia who show partial response to clozapine treatment. J Clin Psychiatry ; Clozapine has a compulsory monitoring service whereby the full blood count of patients is monitored on a regular basis to detect agranulocytosis a significant decrease in the number of white blood cells, which could predispose to potentially fatal infections.
Combined clozapine and electroconvulsive therapy. Convuls Ther ;9 4: Antipsychotic polypharmacy in a treatment-refractory schizophrenia population receiving adjunctive treatment with electroconvulsive therapy. The training consists of 8 modules and can be obtained cost-free from the internet in 15 languages.
Psychosocial[ edit ] Psychotherapy is also widely recommended, though not widely used in the treatment of schizophrenia, due to reimbursement problems or lack of training.
World J Biol Psychiatry ; Upon initial titration with clozapine to a maximum of mg BDour patient became quite sedated a very common side effect of initial clozapine titration. Delayed onset, protracted delirium and aspiration pneumonitis associated with a combination of clozapine and electroconvulsive therapy.
Competing Interests The authors declare that there is no conflict of interests regarding the publication of this paper. The conditions include high blood pressure, excess body fat around the waist, abnormal levels of cholesterol and triglycerides and insulin resistance.
He is a nonsmoker with a BMI of Maintenance ECT for recurrent medication-refractory mania. At 3-month assessments, Positive and Negative Syndrome Scale total scores had decreased more in patients treated with clozapine than in patients treated with quetiapine or risperidone but not olanzapine.
View at Google Scholar S. Notably, these include a risk of agranulocytosis and myocarditis.In this study, the authors compared switching to clozapine with switching to another atypical antipsychotic in patients who had discontinued treatment with a newer atypical antipsychotic in the context of the Clinical Antipsychotic Trials for Interventions Effectiveness (CATIE) investigation.
chotic Trials of Intervention Effectiveness (CATIE) investigation. This phase 2 study was rec-ommended to individuals who poorly tolerated their previous treatment, but it also included 1) ment with clozapine for treatment resistance; cur-rent pregnancy or breast-feeding; or serious and unstable medical condition.
Clinical Pharmacokinetics of Clozapine in Chronic Schizophrenic Patients Y. F.
Cheng 1, T. Lundberg 2, U. Bondesson 3, L. Lindstrrm 2, and J. Gabrielsson 1 clozapine in chronic schizophrenic patients after the more extensive investigation of the pharmacological and clinical effects of clozapine. Materials and Methods Subjects Ten.
Appropriate management of clozapine side effects fa- cilitates a maximization of the benefits of clozapine treatment, and physicians and patients alike should be aware that there is a range of benefits to clozapine use that is wider than its risks.
Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am J Psychiatry. ;(4) The specific aims of this investigation are to 1) assess the acute treatment efficacy of clozapine in treatment-resistant mania, 2) to investigate the functional anatomical correlates of mania, and 3) to investigate the effects of clozapine treatment on cerebral glucose metabolism and metabolic correlates of effective antimanic, clozapine.Download